|
KMID : 0603820080140010063
|
|
Journal of Experimental & Biomedical Science
2008 Volume.14 No. 1 p.63 ~ p.68
|
|
|
Inhibitory Effect of Aqueous Extracts from the Fruit Body ofLentinus edodes on Rat Intestinal Mucosa α-glucosidase Activity and Reducing the Increase of Blood Glucose after Streptozotocin-induced Diabetic Rats
|
|
Lee In-Soon
Chae Heui-Jun
Moon Hae-yeon
|
|
|
Abstract
|
|
|
|
The aqueous extract from the fruit body of Lentinus edodes was evaluated for inhibitory activities against α-glucosidase isolated from Spargue-Dawley male rats. A aqueous extract of Lentinus edodes exhibited 13.8% inhibitory activity on using 2 mM p-nitrophenyl α-D-glucopyranoside as a substrate (IC50 75.3 ㎎/ml). The aqueous extract of Lentinus edodes inhibition type on α-glucosidase was determined to be competitive inhibition. When it was oral administered to increase of blood glucose levels after STZ-induced in a dose dependent dietary. These results suggest that aqueous extract of Lentinus edodes effect a metabolism of intestine, and thereby reducing the increase of blood glucose after STZ-induced.
|
|
|
KEYWORD
|
|
|
Lentinus edodes, α-glucosidase inhibitor, Diabetic rats
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|